GLP-1 Plateau - what happens when we stop?

[snug_midjourney]

Different people respond differently depending on the formulation, and there's a growing list of options on the market with more coming. Ozempic brought a genuinely tough six months, but it did the job, diabetes got under control and a lot of weight came off. Talked it over with the doctor and switched to Mounjaro because of how rough those side effects had been. This one's been nearly side-effect free personally. Everyone's response really does seem to be its own thing.

Staying on top of regular checkups with a physician matters a lot here, and self-adjusting dosage without guidance isn't a good idea.

 

[chickpea_recomp]

Really appreciate the solid advice instead of the usual trolling in these threads. Anyway, the struggle comes down to fatty liver disease. Wanted to switch to Ozempic because of side effects from Mounjaro even after two years on it. The GLP side is doing its job, it's just the GIP hormone that isn't pulling weight loss along. I'm 50 and had cancer back in 2025, so HRT is off the table given it was uterine cancer. My doctor's ruled out hormones entirely. Also discussed with my doctor how switching medications sometimes restarts weight loss, though my liver condition responds well to either Ozempic or Mounjaro regardless. Everyone's situation is different, I know.

 

[rusty_climber]

GastricEmptyOut At first Ozempic worked, later it faded, so I took a year off. With strict eating I held my weight, and after a surgery I couldnt use it anyway. Now Im on Mounjaro, two months on the lowest and now moved up to five. Im not hungry and have zero symptoms. Ozempic made me suffer.

 

[Kyle Clinton]

Yes, do what your doctor says. Have you been tested for insulin resistance? Your feelings make sense to me, I tried every diet out there, I'm very active and hit the gym often, and I tried metformin and Saxenda too, nothing worked. I saw this as my final option and got nervous when results didn't show. Anyway, if Ozempic isn't working you could change to Mounjaro. My doctor told me you need at least 3 months on Ozempic to really tell whether it works.

 

[kcryland]

Really comes down to what was driving the weight gain to begin with, lifestyle, insulin resistance, diabetes, PCOS, sleep apnea, inflammation, disordered eating, whatever the mix is for you. As long as the underlying cause keeps getting addressed through other means, lifestyle changes, other medications, that kind of thing, things should hold up once mounjaro stops. If that root issue doesn't keep getting managed, it probably won't.