GLP-1 woes... what next?

Hong Kong Yanpep International
ThinGal339

ThinGal339

Active member
So, I started with tirzepatide, got up to 10mg, but didn't really drop any weight. I was super tired all the time. Then I moved to reta, also at 10mg, and didn't lose weight, but at least I felt okay. Now trying cagrilintide, and it's making me feel down. I'm at a loss. Any suggestions?
 
Are you at a healthy weight already? Maybe that's why you aren't losing any weight? Did you try semaglutide? I heard some people don't lose weight on tirz until they get to 12.5mg or 15mg. Everyones different tho, but dont forget calory consumption, protein, exercise, sleep, stress etc
 
I haven't tried sema yet. I'm a little scared to try it because I had a bad experience with cagri. My BMI is 29. I'm thinking of trying tirz again, but slowly this time.
 
Why don't you want to try sema? Just curious. Cagri and sema are different. But you could have success on tirz. Do you have any metabolic issues, like PCOS or insulin resistance, that could mean you need higher doses to lose weight?
 
I agree with MochiMuncher, maybe give sema a try. I lost more weight on sema than tirz. It suppressed my appetite more. I'm on tirz and cagri for maintenance now. I had to stop sema eventually because of the side effects.
 
Thanks everyone for the suggestions! I am going to try to max out on Tirz, maybe 12,5mg, if that does not work, I am going to try sema (after doing some research about the side effects. I think I am going to start tracking my macros and doing some light exercise.
 
Tracking your macros and doing light exercise is a great idea! It's so important to have realistic expectations about these medications though. They can be helpful, but they aren't magic. Make sure you are eating enough protein too, it'll help you feel full and prevent muscle loss.
 
Be careful with these new drugs! Some are poorly studied experimentals. Be sure to research everything before trying it out. Know the risks!
 
The side effects I got from sema were mostly gastrointestinal stuff lab-rat-life. Nausea, constipation, sometimes the runs... nothing too crazy, but enough that it wasn't sustainable for me long-term. Everyone reacts differently though!
 
real talk tho — storing 2+ yrs of peptides feels risky. the industry moves fast, and you might just end up with outdated stuff while everything else has evolved.
 
Prior GLP-1 exposure changes how the body responds on restart - tolerance builds and the starting dose rarely matches the original effect. Most people in that situation need to get to a higher dose or try a different compound.
 
Really hear you, and sorry this route might not pan out for you. Part of me still thinks a slow, gradual approach to building tolerance makes sense in theory, but I completely get how discouraging it is going through all the downsides with nothing to show for it. Might be worth finding a genuine obesity medicine specialist, someone who's well-versed in the full range of options out there, not just the two most talked-about medications. Also worth keeping an eye on what's still in the pipeline, there are newer approaches in trials right now that don't even rely on the same biological pathway these current ones use. So much research happening across different mechanisms for weight management that I'd bet there'll be several more solid options within a few years. Best of luck to you!
 
There were participants across all the trials who simply never dropped weight, and there's a decent chance their hunger never actually got suppressed either. Give the fourth or fifth compound a shot since it targets a different receptor entirely, but otherwise it sounds like your body just isn't very responsive to this drug class in general.
 
Stepped away from posting for a bit after getting seriously sick following two doses of a new compound. Feeling somewhat better today, so wanted to circle back and share my experience.

Quick recap: ran one compound for six months with absolutely no weight change. Appetite actually grew alongside dose increases, and the side effects worsened right along with it. Moved to a second one next, then most recently a third. The second did nothing noticeable even at 2mg. The third seemed promising the first few days before reverting completely, zero suppression even at higher amounts. All three brought severe digestive side effects.

My real goal here is quieting food chatter, not weight loss specifically, though oddly I dropped twelve pounds during the month I was off the first compound entirely, waiting for it to clear before trying the others.

Took my first 250mcg dose of the new compound at the end of July. Gave me remarkable mental clarity and shut down food-related thoughts unlike anything else I've tried.

Second dose came the following day, and that's when severe, sudden abdominal pain hit. Bad enough I seriously considered the ER.

Stopped immediately, and the pain's gradually easing now. Considering trying a smaller amount next
 
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