GLP-1 woes... what next?

[ThinGal339]

So, I started with tirzepatide, got up to 10mg, but didn't really drop any weight. I was super tired all the time. Then I moved to reta, also at 10mg, and didn't lose weight, but at least I felt okay. Now trying cagrilintide, and it's making me feel down. I'm at a loss. Any suggestions?

 

[M_R_S_Health]

What was your diet like while taking those meds? And what was your exercise routine? Meds are great, but they don't do all the work.

 

[SnackNoMore]

I'm surprised you didn't lose anything on that much GLP-1. You must be close to your ideal weight already.

 

[not-giving-up]

How long did you try each one? What were your macros like? What's your exercise plan? And what's your starting weight and height?

 

[MochiMuncher]

Are you at a healthy weight already? Maybe that's why you aren't losing any weight? Did you try semaglutide? I heard some people don't lose weight on tirz until they get to 12.5mg or 15mg. Everyones different tho, but dont forget calory consumption, protein, exercise, sleep, stress etc

 

[ThinGal339]

I haven't tried sema yet. I'm a little scared to try it because I had a bad experience with cagri. My BMI is 29. I'm thinking of trying tirz again, but slowly this time.

 

[MochiMuncher]

Why don't you want to try sema? Just curious. Cagri and sema are different. But you could have success on tirz. Do you have any metabolic issues, like PCOS or insulin resistance, that could mean you need higher doses to lose weight?

 

[Great_Ave]

I agree with MochiMuncher, maybe give sema a try. I lost more weight on sema than tirz. It suppressed my appetite more. I'm on tirz and cagri for maintenance now. I had to stop sema eventually because of the side effects.

 

[lab-rat-life]

Side effects you experienced on Sema? Great_Ave TY

 

[ScaleVictory]

I am also curious about semaglutide... I keep hearing about it. Is it really that much better than the others?

 

[ThinGal339]

Thanks everyone for the suggestions! I am going to try to max out on Tirz, maybe 12,5mg, if that does not work, I am going to try sema (after doing some research about the side effects. I think I am going to start tracking my macros and doing some light exercise.

 

[M_R_S_Health]

Tracking your macros and doing light exercise is a great idea! It's so important to have realistic expectations about these medications though. They can be helpful, but they aren't magic. Make sure you are eating enough protein too, it'll help you feel full and prevent muscle loss.

 

[lab-rat-life]

Be careful with these new drugs! Some are poorly studied experimentals. Be sure to research everything before trying it out. Know the risks!

 

[Great_Ave]

The side effects I got from sema were mostly gastrointestinal stuff lab-rat-life. Nausea, constipation, sometimes the runs... nothing too crazy, but enough that it wasn't sustainable for me long-term. Everyone reacts differently though!

 

[apricot-stroller21]

Similar situation here with the partner. Pre-diabetic, triglycerides high. Hoping the next labs show some improvement like yours did.

 

[MoodyLog]

real talk tho — storing 2+ yrs of peptides feels risky. the industry moves fast, and you might just end up with outdated stuff while everything else has evolved.

 

[Busy-Crew]

Prior GLP-1 exposure changes how the body responds on restart - tolerance builds and the starting dose rarely matches the original effect. Most people in that situation need to get to a higher dose or try a different compound.