Got severe eczema flare after increasing reta to 4mg - anyone else?

[Light_Life]

Hello! Ever since moving up to a 4mg reta amount around two months back, eczema decided to show up on the eyelids out of nowhere. Zero history of eczema before this.

Dosing schedule runs four weeks on, one week off. During that off stretch, it genuinely looked like a new cream had finally solved it for good. But after last week's dose, it's flared back harder than ever, now creeping under the eye too. That same cream isn't touching it anymore.

Nothing else in the routine shifted except the reta amount. Beyond a slightly quicker heart rate and mild tiredness, nothing else seems off.

Others have mentioned running into this same rare reaction before. Genuinely unsure whether reta's directly responsible, or if it's just uncovering some pre-existing sensitivity. Stepping the amount back down either way, though any input's welcome. Thanks!

 

[S-T-P-72]

That sounds rough, especially right on the eyelids. Might be worth patch testing a different cream since the one that worked during your off week clearly isn't cutting it against the higher dose flare.

 

[ByeByeBackfat]

Was this your first time up at 4mg or have you been there before and it's just now showing up? Sometimes these reactions take a cycle or two to show themselves even at a dose you've already run.

 

[Fat_No_More_50]

Checking back in on this one, did stepping back down help at all? Curious because I haven't heard many people mention eczema specifically with reta before, usually it's the GI stuff that gets all the attention.

 

[saltynoodle59]

It works, but at the injection spot a raised red welt forms and lingers for roughly a fortnight. NAD+ does the same to me, so maybe it's the bac water? I haven't tested bac water alone. Odd skin pain shows up too, likely because I raised the dose too fast, or it's simply how I react to Reta. Three weeks at one dose now, and it's gentler than that rough first week of the increase, though it's still around. Taking Xyzal in the morning and Zyrtec at night seems to calm it somewhat.