High T while on GLP-1s...anyone else?

Hong Kong Yanpep International
Standard titration is 4 weeks at 0.25, then 4 weeks at 0.50. You already know you ate what you shouldn't have, now you're paying for it. Eat small meals throughout the day instead. Calculate your TDEE and macros online, make sure you're fed. Drink water like it's your job. If you get blocked up (common) take fiber or a gentle lax daily. Talk to your doc about titration and sides—they might keep you on a lower dose till it settles.
 
Been at 0.25mg for 2 weeks and it's helping with body temp and mental stamina. Don't get as burnt out doing office work. I'm in my 30s, worked in competitive white collar most of my career before getting sick. Used to have to break up work and crash. Not anymore.
 
that 1mg box you have is the final dose in the titration, not the starter. you get 8 doses of 1mg after you work up from 0.25 and 0.5. you can use the pen but you gotta dial down—look up the click-tables to find what 0.25mg looks like. and definitely check with your pharmacy!
 
Just got bumped to the lowest dose of phentermine after stalling at the higher one. Only a couple days in so we'll see. Just wish it worked like before without the constipation and nausea.
 
In Australia, if testosterone's low and weight's an issue, usual advice is lose weight first, not my favorite approach, but reta plus weight loss often bumps testosterone enough that supplementation isn't needed. The US prescribes testosterone therapy for older men with borderline levels more readily, unsure about Canada.

A recent study showed a notable life-expectancy jump for colon cancer patients also using glp therapy. Far from proven, but early studies point the same way, plus a comparable finding with a different cancer type. Another possible upside worth weighing. Nothing studied yet on the newer triple agonist and cancer since unapproved, but seems to mirror tirz and sema elsewhere.

No idea if testosterone therapy affects cancer growth, get a specialist opinion first.
 
Came across a discussion elsewhere about targeting actual symptom improvement rather than chasing a specific lab number, which can sometimes happen at a lower dose than expected.
 
Just anecdotally, going on trt as someone planning to stay male, noticed my appetite climb. Growth hormone added even more on top of that. Might be worth bumping the tirz dose a bit to keep hunger in check. Also heads up, testosterone tends to bring some water retention with it.
 
This might explain things better.
Once goal weight got hit on this medication, testing revealed low t, so TRT started too.
The initial amount pushed levels higher than intended, which brought elevated IGF and z-scores plus some weight along with it.

Gained 7lbs while still holding at 15mg tirz weekly.
With a better balance dialed in now, lower igf and t, the number's coming back down and stabilizing.
Weight's held steady for six months straight at that same 15mg amount.

Suspicion here is that the added hormone therapy is what's driving extra hunger and offsetting further loss, so it's landed on maintenance rather than continued drops.

Sounds like a similar situation, the meal plan might just be fighting hunger signals while the underlying issue is really the body asking for more to support those elevated igf levels.

What do the igf and z numbers look like currently?
 
Would you classify yourself as overweight or in the obese range? Given reta started two months back, I'm guessing there's weight to shed here. The starting A1C leaned a bit elevated, borderline prediabetic territory, and combined with moderately raised triglycerides, that pattern points toward metabolic syndrome.

The rest of the lipid panel, LDL especially, probably carries more weight long term for cardiovascular risk and whether statins become necessary. A triglyceride number that's only mildly elevated on its own usually doesn't need aggressive treatment beyond maybe a fish oil supplement or a prescription omega-3. My guess is staying on reta and continuing to lose weight will keep bringing those numbers down naturally. Just keep an eye on blood pressure too.

Reta's already pulled you out of prediabetic range, and while I haven't seen dedicated research on reta specifically preventing diabetes, possibly because it hasn't been studied yet, tirz has shown remarkable results making that progression from prediabetes to full diabetes unlikely, and reta's mechanism suggests it could match or even exceed that. On that basis alone, staying the course with reta seems well worth it.
 
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