Higher dose = more weight loss?

Hong Kong Yanpep International
Because a major clinical trial found that participants on tirz generally stopped losing weight around roughly a year and a half in, regardless of dosage level.
 
Started this on the 27th and this morning landed at a solid amount lost, so honestly even slower than the pace mentioned here. That said, hunger and cravings feel dramatically different now and the mental food chatter has largely quieted down, so clearly the medication's working. Solo effort before this never managed more than a small amount lost over several years.

Sounds like the dose probably just needs to keep climbing.

Based on trial data comparing different weekly amounts of this medication, the jump between a moderate amount and double that produces a dramatic gap in typical outcomes. Going even higher barely adds much beyond that though. So the lower amount really just counts as the starting therapeutic level. Worth continuing to raise it gradually.
 
Every GLP study out there shows weight loss tapering toward zero around the one-year mark or slightly beyond. How much titration speed actually factors in isn't totally clear, though it's possible that assuming dose escalation runs three to five months, loss then slows around nine months into holding the top dose. My read on this is mostly that this simply reflects how long the body takes to reach that plateau point, rather than the medication itself becoming less effective over time.

Hard to fully buy that if someone's held a lower amount, say 5 or 10mg of the dual-action drug, for a year and progress stalled completely, bumping the dose then would do absolutely nothing. Might just be somewhat less impactful than raising it earlier would've been.

One reason faster titration might make sense: after roughly a year of reduced intake, metabolic adaptation really starts kicking in, meaning daily energy burn drops lower, making further loss tougher than it was near the start, and that drop can be substantial, maybe around 20 percent, so for the same appetite suppression or same calorie intake, the gap between ex
 
A relative of mine dropped well over 50 lbs on a moderate weekly amount over roughly a year. She's landed at a normal weight already while I'm still working toward goal. So there's that.

Not saying skip titrating up. And given how much you're aiming to lose, I wouldn't drag things out too long. Would get to an effective dose fairly quickly and keep climbing from there once progress starts slowing.
 
All things equal, the right tirzepatide dose will probably put you in the normoglycemic range, the goal. Sounds like you'll reach a 'normal' weight too, which helps keep glycemic control good long term. Like most medications, take the smallest effective dose. Certain people never need more than 5mg. In my case 10mg suited best for very steady normal glucose, and I've lost 136lbs so far, with another 40lbs to a 'normal' BMI! Keep up the diet and exercise. Your body's transformation will astonish you :-)
 
People here really seem to think the dose, not eating less and moving more, is what drives loss. Feels like built in excuses. Its simple: a calorie deficit from eating and moving is what produces loss. Lots of people assume a higher dose, without a lifestyle review, is the immediate answer. 12 weeks at 2.5mg for me, nearly 30 lbs down, though i bust my butt to get there.
 
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