Started this post-menopause with metabolic syndrome plus PCOS, and didn't see real movement until the top couple doses. Took my BMI down from 36 to roughly 20 over about two years, then lost another 15 slower during maintenance after. Lately I've bounced between 15 and either 7.5 or 10, going by click counting. Started back in December 2023. Maintenance has always been my weak spot, so I held off on titrating down and ran 15 longer to feel solid, that dose genuinely suited me best. Put a few pounds back on at 7.5 weekly. Also tried spacing the 15 dose out, adding a week then two or three between shots, hated the rollercoaster, fatigue and nausea after a longer gap hit way harder than weekly ever did. Everyone's mileage varies a lot with this stuff.