Looking into intranasal oxytocin dosing ranges

[slim_pretzel6411]

Started reading up on making a nasal spray with oxytocin and the dose figures surprised me, they are way smaller than I expected. What I dug up from clinical sources: roughly 10 to 48 IU a day intranasal. The low end, 10 to 20 IU once daily, gets mentioned for general wellbeing. Somewhere around 20 to 24 IU gets cited when the goal is easing social anxiety or building closeness. Higher protocols run 24 to 48 IU split across two doses, and there is a 40 IU pre-session dose for PTSD work. Onset seems to be 15 to 30 minutes.

Storage is the part I want to get right. No preservative means it only lasts 48 to 72 hours in the fridge at 2 to 8 C, so my plan is to freeze small aliquots, thaw one at a time and keep only that one cold. I also read that sterile saline is the diluent here, not bacteriostatic water. Does that match what others do? Has anyone built a sprayer and can share how it went?

 

[Shrinking_Suzi]

Been on 20 IU a day for a few weeks, all in one go in the morning. I notice something about 20 minutes after, mostly feeling calmer around people, nothing dramatic. I'd start at the low end and only move up if a full week gives you nothing.

 

[wk6-soon28]

Freezing small aliquots is what I do too. Thaw one, keep just that one in the fridge, and toss whatever is left at the three day mark. I use a small pump bottle rinsed with sterile saline, and I test-spray water first to see how much one squirt really delivers before I trust any IU math.