Mazdutide: Retatrutide's cousin?

Hong Kong Yanpep International
RetaReadyy

RetaReadyy

Well-known member
They did a 48-week study on mazdutide, playing with the dosages. Seems those on the highest dose, 16 mg, shed over twice as much weight compared to the 6 mg folks. Though, the 6 mg group mostly stuck to 3 mg, bumping it up later. Nausea hit 60% of the high-dose crew.

Hsia, et al. (Poster - Obesity Week 2025). Mazdutide (LY3305677) in Participants With Obesity or Overweight - A Phase 2 Dose-Finding Study. https://assets.ctfassets.net/mpejy6...5_HSIA_MAZDUTIDE_SYMPOSIUM_DV-037120_V4.7.pdf

Those 16 mg users dropped about 22% of their body weight.

Pretty close to the 24% loss seen with retatrutide at its max dose in a similar timeframe. Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972.
 
Reta's good, but some people don't react well. Same with semaglutide and tirzepatide. I'm on mazdutide myself, but I'm not saying anything about results since it's only been a couple of weeks.
 
I'm doing a weird dosing thing. Probably too much for most. I use a spreadsheet I found to track the amount of mazdutide in my system. I aim to increase the level by 0.2 daily. The half-life of mazdutide has a wide range, but I'm using 10 days for the calculation. I think I read 10 days is the average, though I can't remember where I saw that.
 
So you're using mazdutide by itself? Most people seem to be stacking it with survodutide, so there isn't a lot of solo use info available. I'm curious to hear how it works for you, if you aren't stacking. Otherwise, nevermind! 🤣
 
The once-per-day dosing is uncommon in tests. I use it to help my body adjust better to the newer GLP-1 meds. It also minimizes peaks and valleys. Once-weekly dosing is likely based on convenience. I think this minimizes side effects. But trials would need to be conducted to determine whether my belief turns out to be correct.
 
I agree, it's probably easier for trial protocols. I take reta with cagri twice a week, and I feel fine. I hate the food noise on days 5 and 6 when dosing weekly. More trials are definitely needed!!
 
I had some annoying ones with tirz, like sulfur burps, a bit of diarrhea, and sleep issues at first. Nothing terrible, though.

Oh, and I get the crazy reta dreams! Nightmares sometimes.
 
Here's a graph of previous trial results compared by weight loss percentage. It's a bit misleading because of the different timeframes. I estimated where they might be at 48 weeks, similar to the Reta trials. Mazdutide was close to Reta's level, and Cagri-Sema was even closer.
 
You need doses of 10-16 mg of mazdutide to get Reta-like results. I'm basing this on the mazdutide studies, which weren't direct comparisons. There was a recent 48-week trial with 10 and 16 mg doses.
 
Where did that study come from? Maybe you mentioned it earlier? It shows the 6mg dose working well up to 24 weeks. I realize the loss slows down, so my estimates aren't perfect. I'm assuming they all slow down at the same rate, which isn't accurate. Does mazdutide have less effect on the liver?

I think someone mentioned glutathione is good for liver health. Are you looking into that?
 
Weight loss meds usually reduce liver fat. But drugs that activate glucagon receptors (GCGR) lead to a bigger reduction. Low liver fat is good. Mazdutide and survodutide activate GCGR. Retatrutide is the most studied weight loss medication in this class.

I don't know much about glutathione.
 
I did have high ALT levels, like 10x the normal limit. I didn't want to try anything for my liver without my doctor's okay. I'm not saying anything would have worked or not; it's just what I thought.

My hepatologist and I didn't think retatrutide was causing the liver issue, but we stopped it as a precaution. I also stopped Lipitor. My ALT is now down to 2x the normal limit, which is okay.

I might start retatrutide again.

He did a Fibroscan and said I don't have fatty liver, though I may have before.
 
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