Mood swings on Reta?

Blair75

Blair75

Well-known member
Hey everyone, I'm curious to know about mood changes with Reta. Any experiences you can share? I'm mainly worried about irritability. Has anyone felt more easily annoyed while taking it?
 
Nope, Reta is my first dive into this. I'm taking half a mg twice a week, so one mg total weekly, and I'm only in week one. I might just be cranky about something else, but I figured I'd ask. It started happening around day three. Could be coincidental, I was feeling fine at first.
 
I wouldn't be so quick to blame the Reta, especially since you've only been on it a short time and the timing might just be a coincidence. But I know higher doses of Tirz can cause a loss of pleasure in some, so it's not impossible that Reta is the culprit. Were you experiencing other side effects when you felt irritable?
 
It can do stuff to your emotions, like the anhedonia. I feel all blah on 8 milligrams per week, but splitting the dose helps. I agree with @yoyofat.
 
Could it maybe be a secondary thing? Like, maybe you're low on energy or just tired, and THAT'S making you irritable?
 
Oh man, I've been having that issue on tirz, so I've been looking into reta hoping to avoid it. I'm also hoping for reduced appetite suppression and less fatigue and nausea.
 
I want to switch, but I'm so worried. I keep hoping to find someone local who is using reta. I've been reading too many conspiracy theories and I have terrible luck, so I'm convinced I'll get a bad batch. Hearing about your experiences is helping though! Thanks for the feedback.
 
Hey @Scarroll, I'm in the Portland area if that's local enough. If it wasn't for terrible luck I'd have no luck at all kind of person. Up until I started Reta. I've been on it for two months now and it's amazing. I can actually stick to a restricted calorie intake without constantly battling cravings. Plus, no shady characters in suits have shown up at my door yet. For the original poster, I was a bit crabby when I first started Reta. I'd say it lasted the first couple weeks. Looking back, I think it was because my calorie intake was too low, I didn't have any pep, and my body was adjusting to the lower calorie intake. By the third week, I had my food figured out and found my pep returning and my mood improving.
 
Isn't being grumpy sometimes related to low glucose levels? I seem to remember someone I know needing a snack to calm down. What do I know... I am not a medical expert.
 
From what I've read in research about GLP's, and I admit there's less info on retatrutide specifically, there doesn't seem to be a significant overall effect on mood, depression, or suicidal thoughts. Except, mood improves with weight loss, whatever the cause. People respond differently, and there are anecdotal stories of fatigue or loss of pleasure. Mood is also very responsive to placebo effects. Antidepressant trials often show a 70% positive response for the drug and 50% for the placebo. I think that this effect is probably stronger than any actual biological effect on mood, so what you EXPECT going into using the medications is important. Since the original poster was worried about the effects on mood BEFORE starting reta, they might be experiencing a nocebo effect. The studies suggest there is no substantial effect on mood except for IMPROVING it once weight loss occurs. Don't worry about it unless it happens, and then you can stop or try a different GLP.
 
Agreed! Do your homework, be careful where you buy, check your product. Read reviews, ask here. Learn how to mix it and be safe, and write down your vial strength, how much bac you use, etc. And keep double-checking if you're nervous. Use a filter. I use pepmath.com. As safe as you can get, with non-pharma.
 
Tiredness is a frequent side effect on Sema over 10 percent, and Tirz 1-10 percent. About mood, I'd agree it's unclear. But I wouldn't NOT use it just because of other people. I didn't think I'd get anhedonia. I looked it up AFTER I felt it, because it seemed strange. But you are right, I tell my patients, don't read about side effects, I'll tell you what's most common.
 
Hi @damy2604, I think irritability can be linked to the drug's effect on your system, but that might not be the ROOT cause of the problem. I have a metabolic issue and have had mood dips since I was a teen, along with some serious bouts of depression. I also unfortunately have a history of mood and addictive behavior in my family. As women know, hormone fluctuations can make you irritable, and men can have mood changes linked to testosterone. So the way these pathways connect with the things GLP-1s affect MIGHT impact that element of mood. This made me careful about the impact of GLP-1s on seratonin and dopamine. We need more research here. So going 'low and slow' is the right approach. Let's not dismiss the theory that depression is caused by an inflammatory response. GLP-1s CAN help with that. As with side effects, only you know what you're willing to put up with. It's your first time and you haven't seen the benefits yet. Studies show side effects get worse as people increase the dose. For me, the benefits are worth it. You're already split dosing so that's good. The irritability will probably fade, but I'd also suggest getting enough carbs in your diet, maybe focusing on day three as you mentioned. Write down your symptoms to figure out those irritable days.
 
Another vote for split dosing. I had awful GI problems, allodynia, and tiredness when I tried to titrate to 4mg once a week. But taking 2-2.5mg twice a week helped. I don't THINK I've had much irritability, but it's hard to tell. I'm dealing with normal hormone stuff from my cycle, plus moving and starting grad school and planning a wedding... anyone would be stressed. I won't blame any peps for that. I hope you find something that works for you.
 
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