Mood swings on Reta?

[Glp-Won-Kanobi]

It could be low blood sugar, Blair75, I know that if I don't eat regularly, I can get quite irritable! I've had to grab a sugary drink before to stop being so cranky.

 

[Pep_552]

I've also heard that some people are secretive about using weight loss meds because they don't want to deal with other people's judgments. I can see that, honestly. People can be real jerks about it, like it's not "real" weight loss or something.

 

[StallBreaker]

I've seen some people say that sema made their mental health worse. Has anyone switched from tirz to sema and felt better?

 

[InsulinResistant]

People can be real jerks about it, like it's not "real" weight loss or something.

Yeah, I've seen that too. I think some people are just jealous or feel insecure about their own struggles with weight, and it comes out as negativity towards others.

 

[SnackSet]

I haven't experienced irritability, but I can definitely say that the 'food noise' disappearing has helped my mental health. I don't feel like I'm constantly battling cravings anymore. Less stress overall.

 

[lankysourdough45]

The anhedonia pattern is more commonly reported with reta than with tirz, probably because of the broader reward pathway suppression from the glucagon component on top of the GLP-1 mechanism. If mood and drive are already intact on tirz, it's a good indicator the dopamine pathway isn't heavily affected.

 

[VialGains]

Reta stopping at week 3 with no dosage change making a difference and then Tirz hitting immediately is the experience that confirms the individual receptor response pattern. For the OP asking about mood on Reta - the GIP receptor response on Tirz tends to be more reliable on the mood and energy side than the glucagon agonism on Reta. If mood stability is a priority, Tirz history matters for predicting what Reta might do.