Mood swings on Reta?

Hong Kong Yanpep International
It could be low blood sugar, Blair75, I know that if I don't eat regularly, I can get quite irritable! I've had to grab a sugary drink before to stop being so cranky.
 
I've also heard that some people are secretive about using weight loss meds because they don't want to deal with other people's judgments. I can see that, honestly. People can be real jerks about it, like it's not "real" weight loss or something.
 
Pep_552 said:
People can be real jerks about it, like it's not "real" weight loss or something.
Click to expand...
Yeah, I've seen that too. I think some people are just jealous or feel insecure about their own struggles with weight, and it comes out as negativity towards others.
 
The anhedonia pattern is more commonly reported with reta than with tirz, probably because of the broader reward pathway suppression from the glucagon component on top of the GLP-1 mechanism. If mood and drive are already intact on tirz, it's a good indicator the dopamine pathway isn't heavily affected.
 
Reta stopping at week 3 with no dosage change making a difference and then Tirz hitting immediately is the experience that confirms the individual receptor response pattern. For the OP asking about mood on Reta - the GIP receptor response on Tirz tends to be more reliable on the mood and energy side than the glucagon agonism on Reta. If mood stability is a priority, Tirz history matters for predicting what Reta might do.
 
This genuinely helped my mental state. Thought I was just getting older or coming down with something. But it definitely lined up with switching over to reta. Never dealt with this on Tirz previously. Another reason I'm staying under 4.5mg for now is that skin-tingling sensation kicks in past that threshold.
 
Pretty sure reta's been messing with me too. Been noticeably more down than usual ever since starting it. Things that used to bring me joy just don't land the same way anymore. Sex drive has completely disappeared, which is genuinely out of character for me. Can't blame hormones either, officially crossed into postmenopause just last month.
 
Basically dulled reactions to stuff that should register as good or bad. Kind of like being oddly detached from something that should genuinely hit you emotionally either way. Should be noticeable when it happens. My amount is pretty small, 1.8mg, and I started the third compound back in April. Not certain the two are connected, but for what it's worth, my emotional flatness isn't severe and it doesn't seem to change my actual behavior, though it does shift how I FEEL about certain things somewhat.
 
Honestly reta's anhedonia has been a big upgrade for me. I have bipolar disorder, mostly on the depressive side, and I'm a recovering addict, so my baseline before reta was constant suffering. Feeling flat is a relief. Four months in, and I've stayed under roughly 5mg weekly. Anhedonia supposedly hits harder on bigger doses. But a lot is going on behind the scenes to keep this manageable, and I couldn't see doing reta without my supplements sorted. I take benfotiamine, calcium pantothenate, riboflavin, P5P, methylfolate, plus B12 in sublingual form. Also trace minerals (boron, copper, zinc), lots of magnesium, D3/K2, taurine, TMG, glycine, fish oil, salt and potassium in my drinking water, and lately lithium orotate, which has done wonders for obsessive and anxious feelings.
 
Past roughly 5mg a week I fall into a terrible funk. Just be aware, it's common and pretty rough when it hits. It happened to me twice, and each time I had to stop reta completely for 2 months.
 
About four months on tirz, with a month of reta stacked on top, and honestly no mood swings so far, not early on and not now. Its been steady for me. Everyone reacts differently, so I watch for any shifts, but it has been smooth sailing on this front. I have seen plenty of people say the mood ups and downs show up early and settle as the body adjusts, so hopefully thats you too. The first month seems unpredictable for some, but it doesnt have to stay that way.
 
Feeling this with you honestly. Ran Reta for three months and dealt with some low moods early on too. Switched over to Mounjaro a month back because my sleep was suffering, and now my appetite's roaring back with me eating constantly while also crying every couple days from feeling down. Might just need a bit longer to adjust!
 
You must log in or register to reply here.
Back
Top