My pants are too big now!

Hong Kong Yanpep International
Timing the dose relative to heavy lifting is a real calibration problem - most people find 12-24 hours before the session works better than dosing the same day for compound movements. Torn rotator cuff plus biceps tendinosis is a constraint that significantly narrows the exercise menu; the hip thrust and lower-body work becoming central to the program isn't a compromise, it's just the correct rotation given what's overhead. MOTS-C for energy and recovery gets mentioned in contexts like this where the overhead press shelf is temporarily out of reach.
 
The MOTS timing question depends on what you're doing. Non-workout days fine while it bothers you right before moving fits the pattern people report with higher intensity. What kind of movement triggers it specifically?
 
the above-150 HR threshold for feeling unwell is worth taking as a real signal rather than pushing through - the cardiovascular system adjusts to the medication's effects on heart rate over time but the ceiling for comfortable intensity can sit lower than before, especially in the early months. working at the threshold rather than above it and extending the sessions is the more productive approach
 
10mg and not noticing a cardio or lifting impact is actually reassuring for anyone worried the medication blunts performance. The OP's pants-too-big milestone is the kind of feedback the scale doesn't always give you clearly. If the weight is moving and the clothes are confirming it, something is working even if you can't feel the mechanism during exercise.
 
the objective effects showing up before subjective awareness is one of the more interesting patterns on these compounds - your labs and your output metrics change before you feel different. cardio function tends to be one of the earlier measurable shifts; you can often see improvements in resting heart rate or recovery time before you notice it during activity
 
creatine as a GLP-1 supplement is one of the underused additions - the fatigue from eating at a deficit reduces available cellular energy in muscle tissue, and creatine supplementation partially offsets that by increasing phosphocreatine availability. 3-5g daily is the standard dose; the energy increase is real and most people notice it within 2-3 weeks especially if they're doing any resistance training
 
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