Actually moved up to 4mg this past Sunday. Might just be in my head, but it felt like a noticeably strong shift. Started at 1mg, bumping 1mg every three weeks. Barely noticed anything on the earlier increases, but 4mg hit differently. First off, zero cravings whatsoever. It's Friday night and I've eaten considerably less all week since Sunday. Normally around Thursday I'd start feeling mild pulls toward food, nothing this time. Also was averaging roughly 1kg weekly on the earlier amounts, this week I dropped 1.7kg. Could be coincidence or placebo, but there's genuinely something different about the 4mg level. And for what it's worth, I haven't dealt with any major side effects since starting Reta, and the 4mg jump hasn't changed that. Only thing worth mentioning is ongoing constipation, though manageable, nothing overwhelming. Staying hydrated and eating enough fiber daily keeps it under control...