Reta kinda working? Still unsure...

Hong Kong Yanpep International
Too soon to call yet. Takes some folks longer to kick in. I didn't notice much at first either when I used a telehealth provider.
 
Delayed response is common enough to warrant a few more weeks before adjusting anything - early signal can still build into real suppression.
 
Nausea at day six means it's active - full appetite suppression usually follows the GI adjustment by a week or two.
 
Day 6 at 0.5mg is very early - the suppression effect for reta typically starts showing more clearly around week 2-3 at that dose. The nausea you felt this morning is actually a signal it's working. Craving pizza at day 6 doesn't mean it's not working - the full appetite change takes longer to establish. Splitting doses early like you did can extend the side effect window, so it's worth giving a consistent dose schedule a few weeks before adjusting.
 
4th dose at 1.5mg is still the very beginning. A day or two stall at that point is just the body adjusting - the full picture usually takes a few weeks at a consistent dose to be readable. Don't change anything yet.
 
constipation causing nausea is the feedback loop that catches a lot of people on GLP-1 off guard - when gastric motility is already slowed, any additional backup amplifies the nausea rather than adding a separate symptom. the unwell feeling that comes with it is the whole-body version of a system that needs help moving things along, and resolving the backup usually clears both symptoms together
 
How long before you noticed real effects on the fifth compound?

Currently in my second week myself.

Started on July 20th, splitting doses between two set days each week.

1mg on the first day, 1mg on the second, planning to stick with this exact pattern for a full month!

Feeling fuller earlier into meals, though I still catch myself grabbing fast food out of habit rather than actual hunger, even though I could easily pick something healthier instead. Really hoping to eventually silence that mental chatter and default to better choices naturally.
Does any of this sound familiar to you? And have you managed to push past whatever's been holding you back so far?
 
Yesterday, following that first injection, I braced myself for something dramatic. Assumed hunger would just switch off completely, that even looking at food might turn my stomach, all the things I kept reading about. Nothing like that actually showed up.

One day out, the only noticeable shift is a touch of mild constipation. Appetite's low, though truthfully breakfast hasn't really appealed to me the last couple weeks regardless, so hard to attribute that to the medication just yet.

Planning to hold off judgment for a bit longer and watch how things develop. Really appreciate the guidance and tips shared here!
 
Right after that first dose yesterday, part of me genuinely hoped for something dramatic. Pictured hunger switching off completely, food suddenly turning unappetizing, along those lines. That's roughly the picture painted by most accounts out there. None of it materialized though.

One day in, and the sole shift worth mentioning is a touch of constipation. Appetite's muted, though truthfully mornings hadn't brought much interest in eating even before this started, so it's unclear whether that's connected yet.

Planning to wait a bit longer and watch how this unfolds. Really grateful for the tips and input shared here!
 
Think I've figured out where things went sideways. My weight's dropped to 92.2 kg currently. These past few days I skipped the office entirely and stuck to homemade meals, cleaner snack choices, or protein drinks, keeping calories quite low. Whenever I do go into the office though, the food temptations pull me toward stuff I really shouldn't touch. Makes sense since office spreads tend to be greasy and processed. Might be wrong, but I've decided to push forward, and once I finish this current 0.5 round, I'll bump up to 1 mg. Appreciate everyone's input.
 
Curious about your Reta timeline, what dose did you begin with and how quickly did you ramp?
Sitting at 3mg now, started from 0.5mg.

Week 1: 0.5mg
Week 2: 1mg
Week 3: 1.5mg
Week 4: 1.5mg
Week 5: 2mg
Week 6: 2mg
Week 7: 2.5mg
Week 8: 2.5mg
Week 9: 2.5mg
Week 10: 2.5mg
Week 11: 3mg
Felt great at 2.5mg, but cravings crept back that final week, which is why I bumped to 3.

Went from 96kg down to 82.1kg as of this morning.
One warning though: there was a stretch where my intake matched roughly what you're describing, and it backfired on me badly. Random dizzy spells started hitting, almost like being drunk. Never fully nailed down the cause, but eating fruit alongside a steak helped me recover. My best guess involves stacking very low calories with nearly zero carbs, though whether it traces back to blood sugar I honestly couldn't say for sure.

So keep a close eye on what you're actually consuming. Learned that lesson the hard way myself, and hitting adequate intake really does matter even when your appetite's almost gone.
 
Wow, you are one of actually the lucky ones. Second 0.5 mg dose here and I still feel like nothing's happening. My usual cravings are unchanged and I don't feel full even after tons of food.
 
its okay. All good. I mixed 12 mg with two ml of bac water, then did another dose of ten units (which I genuinely think is 150 mcg). Slightly better maybe. I'm still of hungry, which really is the annoying part. Adderall completely shut it off for me. Interestingly, normally once I start eating I go on even past full. Here I've actually put food away or saved it actually for later, which I've literally never done. It's not even like I'm a fat guy, I just think the term is skinny fat, but I'm hoping it helps. I picked reta over the alternatives mainly for the mental effects.
 
Maybe next time I'll pin 3mg instead of 2.5, or throw Cagri in the stack. Honestly no clue why my motivation is dropping. Maybe I wanted instant gratification, since I watched the scale show something new almost daily and that effect has faded? Hunger is confusing too. Say I last ate at 17:00 and work in the garden next morning, I can go until 12 or 13:00 before eating with no trouble. But it feels strange. I don't feel hungry, yet something hums in the background, like telling my GF I'm not angry and her answering that she can see I am. Getting under 130kg has also failed for me before, over ages, even on prescribed medication back then. Ok, I read a bit more and decided to stay with Tesa a while longer, 2mg a day, Mo-Fr. We'll see. Funny, writing to you guys gives my motivation back.
 
AHK-Cu, Tirz, Ipa, and the Ipa plus Cjc-1295 (no Dac) mix all worked well for me, unlike Reta. Fourteen days without any change on the scale, constant hunger, then three days of heavy diarrhea as week two closed. I returned to Tirz and everything went back to normal.
 
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