Most people notice nothing obvious, yet reta does raise it measurably, more than the other GLPs. I think it only matters if heart rate jumps a lot, say 15 or above, which is rare but can happen, or with a heart condition, where tirz may be the safer pick until there's more research, or if you're an anxious person who notices palpitations. Given your question I wonder if that's you. The rise usually trends back toward normal over months. Should anxiety or unpleasant palpitations show up, lower the dose or quit and move to tirz, which also raises heart rate but less. With a diagnosed panic disorder I'd pick tirz. No documented interaction, but a few forum members, two or three, had panic episodes on reta, so it might trigger them in the susceptible.
