Reta Phase 3 deets?

[Lab_Mouse_4421]

Hey everyone,

I just started Reta recently and wanted to dig up the official phase 3 clinical trial info. Just trying to stay informed. I've been searching for a bit, but I'm new to this stuff, and any help would be awesome! Thanks!

 

[Lab_Mouse_4421]

Never mind! I think I found it: https://clinicaltrials.gov/study/NCT05929066?term=retatrutide phase 3&rank=8

But it doesn't say what dosages they're using, which is what I was hoping to find out, lol.

 

[Ozempic_Oracle]

Tons of great info over on this reddit: Check out another user's posts. He's a doc enrolled in one of the phase 3 trials. Lots of trial data and personal experiences.

 

[D_Jen]

If you want to know what the results are... good luck. The trials haven't released data yet.

 

[NauseaIsReal]

Is Reta even safe? Seems kinda sus.

Anyway, try searching for Retatrutide studies from the drug manufacturer, the NIH, or the New England Journal of Medicine. They usually have info on the dosages used so far, how long they tested it for, the amount of weight lost, any side effects, etc. The FDA will probably use the same levels when/if they approve it.

I heard the manufacturer tested 1mg, titrating 2 to 4mg, 2 to 8mg, 4mg, titrating 4 to 8mg, and titrating 2 to 12mg. Half-life is 6 days. Do a lot of research.

 

[Choco_No_More]

Way back when, I snagged some dosage info from a New England Journal of Medicine article from June 2023. It covered the dosing and early results from a phase 2 trial.

I took a screenshot of the relevant part for easy access. Sharing it here.

PS. I thought Reta was amazing.

PPS. I had to stop. Heart problems. Major bummer.

 

[Lab_Mouse_4421]

Thanks, Ozempic_Oracle, I'll check out that subreddit!

 

[Big_Tony_NJ]

Be careful with this stuff, I heard some clinics are getting sued for how they compound it. Read this article: https://www.cnbc.com/2025/04/01/eli-lilly-sues-strive-and-empower-over-compounded-tirzepatide.html

 

[D_Jen]

Just a reminder, the legal landscape around compounded GLP-1s is constantly changing. Make sure your clinic stays compliant.

 

[Ozempic_Oracle]

It's not just Ozempic that's crazy expensive! All meds are. My Jardiance is insane, and regular Medicare patients can't afford it. Pharma's gotta chill on these prices. Ethically, it's wrong.

 

[Choco_No_More]

Is Reta even safe? Seems kinda sus.

Just echoing my own experience, be super careful! My heart issues started after a few months. It's effective, but not worth the risk if you have any underlying conditions.

 

[Lab_Mouse_4421]

I saw something about companies fighting back against the big pharma companies, trying to make personalized meds more accessible. Anyone know more about that?