Interesting, I don't notice differences day to day, but several changes stand out. My nasolabial lines improved almost right away (I'm 55, they worried me most). A shoulder stuck near 90% ROM since a frozen shoulder couple years ago jumped to around 95%, a surprise. By week 8 my varicose veins looked better (minor ones), and my skin texture seems improved. Hoping next come stronger nails, more wrinkle smoothing and fewer face spots.