Sema progress - 25lbs gone!

Hong Kong Yanpep International
Covered the cost myself, and Sema ended up being the cheaper option. Twelve months in, I made the switch to Zep because I'd been fighting side effects, mostly nausea and exhaustion, for almost that entire stretch, and couldn't push my dose high enough to get past a five-month stall (Aug-Dec 2025) that came after my first 40 pounds. A few months after switching, I dropped another 30 pounds and these days I'm living pretty much free of any side effects! Wish I hadn't put off the switch just to save money, but honestly the better pick between the two really just comes down to whatever fits you personally.

43, 5'4, 227 back in January 2025, sitting at 155 today.
 
Still holding at just above half dose. The rough side effects have actually been driving a good chunk of the weight loss. Only move up once I've stalled for more than a month straight. Sick most days, running Sema this whole time.
 
Dealt with anxiety for a long stretch and I'm on medication for it. Things became genuinely unmanageable. Not fully sure whether it was the medication itself or some absorption issue, but I was struggling. Leaning toward absorption, since it wasn't until the effects wore off that the dose suddenly felt too strong. Called it a couple weeks back. Down a solid amount, nowhere close to my target yet. Sticking around to see whether anything newer comes out that might suit someone like me better.
 
Only a few weeks into this, still on 0.25mg sema, moving up to 0.5 next week. Really only felt nauseous about four times total - twice tied to work stress (I'm diagnosed with anxiety and PTSD so that tracks for me), twice from waiting too long to eat, which fixed itself once I did. So far it's going well! We'll see how the bump next week treats me.
 
Three months brought 25lb off me, though much of that early drop came from the nausea at the start. Early on there were rough stretches where I could hardly manage food or daily tasks. At roughly 3.5 months in now, I feel far better and only get side effects after something super spicy. Hang in there, worth every bit!!
 
Nine months at 45 units (1.15 mg), which took four months of titration to reach. Bad side effects never really happened to me. My diet got my full attention in the beginning (still healthy, just less obsessive). Days 2-3 post shot were when anything appeared. Eating three proper meals with protein first kept nausea mostly away. I whine loudly about nausea, so you can believe me: I would say so if it hurt. Ginger candies were my backup, and a couple of saltines sometimes did the trick. No dose felt worse than the rest. Nausea is gone entirely these days. Against constipation I hydrate a lot and have senna tea in the evening now and then.
 
ramen-titrating My apo-sema start was July 22, so the four 0.25mg injections are behind me and I'm in week one at 0.5mg. Likely a super responder: the first shot registered, loss started at once, sweets lost their appeal (no idea when I last had chocolate), and food noise is basically muted. I do get properly hungry near meals, preferred to my old all-day and midnight snacking. My weight went 297.8 down to 283.3, jittering a pound or two daily. Side effects were minor: week three brought serious constipation, cured by a big fibre boost. I adore this medication. Living this way permanently would be my dream.
 
I was your size. I began on sema, lost 25 lbs, then quit because I felt so sick and worn out, and put 30 back on before switching to terzepitide. Sema works wonders for anyone who can put up with the side effects, and some people barely get any while the weight melts off.
 
Must just be lucky, I haven't dealt with any real side effects besides the weight dropping fast. My spouse got hit with every single one though. Started at .25 for a month then moved to .5 once the hunger chatter returned. Kept my reta dose steady through all of it.
 
one thing i've picked up is how fast symptoms can shift. never actually got sick but the early nausea hit pretty rough. been on this since mid june and only now feel normal most of the time, maybe 90 percent, while appetite control is still holding strong. seriously don't be scared to grab something for the nausea if you need it
 
Started sema in march last year, 5'3 and 204 pounds. Responded unusually fast, and looking back id have stayed on the dose longer, until suppression wore off or I hit a real stall. Lost 25 pounds the first two months at .25mg. Nausea hit hard after every shot, so my doctor kept me there four weeks. Week five I moved to .5mg, still fighting nausea, stuck with it four more months. Kept losing, another 28 pounds by month six. Stalled in month seven, so moved to 1.0mg, and by the one year mark id lost 63 pounds total, landing at 141. Goal was 125, but major surgery forced a pause, three weeks before and nine after. Shockingly, I didnt gain anything back across that gap. Once cleared to restart, my doctor wanted me moved onto tirzepatide instead, given how severe my nausea had been.
 
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