I held off about 10 days. I AM a type 2 diabetic, so it isn't only for weight. Nervous about reactions, I picked a weekend day for the shot. Nothing happened at all, other than zero appetite. Cravings for meals, takeout and junk vanished, and food stopped filling my head. To me it felt like eating to live, since by day 3 eating was a chore I had to push through. Drink water, and make what you eat high in fiber, avocados are good too, or take a fiber supplement. Things need to keep moving because Oz curbs appetite and slows digestion, so constipation may follow. I'm going up to .50 this Thursday since I think my body has adjusted to .25, cravings are back and I ate a huge Chinese takeout dinner tonight lol. Already down 5lbs.