Dealt with genuinely awful side effects on tiny ozempic doses for a full year before finding more affordable overseas peptide options, so take my opinion with a grain of salt, but that particular medication genuinely ranks as the roughest of the bunch when weighing suffering against actual results. Running a small dose every other day, or even a small weekly amount, gave me far more grief than my current combined regimen of the other three compounds does now.
Mostly because side effects run lighter, tirz beats semaglutide as the better pick, and it also outperforms it for actual weight loss.
Reta holds its own too, just carries a somewhat higher chance of a racing pulse and touchy skin as side effects. That said, you really need to line up an equivalent-effect comparison, a smaller reta dose against a larger tirz dose, to judge fairly, since reta punches above its weight. I'm honestly not certain the side effect gap holds once you correct for that, something like a strong tirz dose roughly matching a much smaller reta amount for weight loss purposes. And at the lower end, a tiny reta dose is probably doing as much work as a moderate tirz dose.
