Tirz 15mg --> Reta dose recs?

Reta hits a slightly different set of receptors than Tirz. I'd suggest starting super low and then bumping it up after a week if you aren't feeling anything. Here's a sample schedule for retatrutide dosing...

Week
1-4 1mg
5-8 2mg
9-12 4mg
13-16 8mg
17+ 12mg
 
I basically did this. I jumped to 5mg of Reta after being on 15mg of Tirz without any problems. I went up to 7.5, then 10mg and stayed there for a while.
 
Given the potential heart-related side effects linked to Reta, I'd advise sticking to the trial dosing. Maybe shorten each stage to 3 weeks if you're keen to speed things up, but risking your cardiovascular health just to increase the dose faster doesn't seem worth it to me.
 
I've actually used both, so I can share my experience. For me, 15mg of Tirz is roughly equivalent to 10-12mg of Reta. I've tested Reta from a few different sources, which is why I say around 10-12. Tirz has consistently felt weaker than Reta. Semaglutide was the strongest of the 3 GLP-1s for me. I couldn't go beyond 1.5mg without major side effects.
 
Update: I gave up on the Reta after three weeks. I initially started with a small dose of Reta in addition to my 12.5mg tirz, and then tried to cut back on the tirz, but I felt so hungry. It seems that Reta just doesn't have the same appetite suppressing effect at the lower doses. I'm going to wait until I'm in maintenance to try it. I still have about 50 pounds to lose. Instead, I've started doing a .3mg dose of cagrilintide midweek, which is working well.
 
I haven't used tirz, but 1 mg of reta weekly has completely crushed my appetite for the last month. I'm a little nervous about going higher. I'm not even sure if I'll bump up to 2 mg. I wake up around 6:30-7:30 AM and barely think about eating until 4-5 PM. I have to set alarms to remind myself to eat something.
 
HealthAF said:
Instead, I've started doing a .3mg dose of cagrilintide midweek, which is working well.
Click to expand...
That's interesting - I hadn't considered adding cagri mid-week. I've been on 7.5mg tirz for a while now and am starting to plateau... might give that a try.
 
For those of you switching between Tirzepatide and Semaglutide, keep in mind Tirz acts on both GIP and GLP-1 receptors, while semaglutide is only a GLP-1 receptor agonist. This might explain differences in effectiveness some people are seeing.
 
I've been making sure to increase my protein intake, and hitting the gym about 3-4 times a week. It's definitely a whole lifestyle change!
 
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