Tirz, Cagri, Sema all at once?

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Slightly_Smaller

Slightly_Smaller

Well-known member
Hi everyone!

I'm very interested in hearing everyone's experiences, good or bad, and any input you might have. I was on 2.5mg of Tirz for a bit, and things were moving, but slowly. I wasn't feeling much in the way of appetite control, and the constant thoughts about food were still there. I moved up to about 3.5mg (after a month and change) and then did a ton of research and got vials of Cagri and Sema.

I took my 3.5mg of Tirz on a Saturday night, and then on Wednesday, I tried 0.2mg of Cagri with 0.2mg of Sema, thinking I could always adjust it down. Besides a tiny bit of queasiness the following day, no real bad effects. But wow, my hunger was totally gone for almost 5 days, but I could still eat small amounts when I needed to. My weight started dropping faster, which was great because I wasn't suffering much in the way of side effects. I was seeing the progress I wanted.

This past Saturday, I lowered my Tirz back to 3mg (testing the waters at the lowest dose possible), and this Wednesday, I'm planning on the same Cag/Sem dose. I've seen a lot of talk about stacking GLP-1s, and I know there's a risk of issues with Sema, so I'm being careful. Anyone else doing this? Any advice?

I should also mention I get a lot of protein (80-120g), fiber, and water, and things are moving along fine, if you catch my drift. No low blood sugar signs either. My blood work was fine a few months ago, just low iron and D, which I'm supplementing now.

I started at about 313 lbs, and I'm down to 292 or so now.

One more thing: I've had terrible inflammation, making my whole body ache, especially my knees. But lately, it's almost gone! Standing up from sitting doesn't hurt anymore! My face is less puffy too. I'm thinking of adding BPC-157/TB-500 or CJC-1295/Ipamorelin (not Tesa, because of my SNRI) later on. Any thoughts on that?

Sorry for the long post. I just wanted to give you all the info up front. Thanks!
 
That's interesting about the inflammation, that would be awesome to see that kind of effect. I think, like others have told me, that you should reconsider thinking that you're the exception to the documented dosage range for Tirz, which is like 8-15mg. I was trying to stay low too (around 4mg), complaining about appetite, and eventually decided to just go up. I'm not sure about the combo of all three, but maybe your Tirz dose wasn't high enough to begin with. If you're getting good results with low side effects on CagriSema, maybe lowering or removing Tirz is an option.
 
I'm with lab-rat-life on this one. Stacking while on a super low dose of Tirz seems counterintuitive. Ride the Tirz out and titrate upwards, paying attention to side effects along the way. It sounds like the Tirz is working for you, especially with the weight loss and the reduction in inflammation that you mentioned. I also had less inflammation when I was on Tirz, and have continued my remission with Reta.
 
Thanks, everyone!

It's not that I'm scared of increasing the Tirz dose. It's more that on day 5 or 6, I get super hungry, and the cagrisema seems to keep those cravings at bay. As for dropping the tirz, I am afraid that the inflammation will return!

Maybe I should split my Tirz dose to 3mg every 4/5 days since I should already be a few weeks into 5mg dosing by now?

Or should I drop the sema instead and stick with tirz/cag?

It's just those last few days of the week that are awful!
 
I had a similar issue, so I switched to dosing every 5 days instead of 7. Lots of people have had success with the 5-day schedule.
 
Eli Lilly (the maker of Tirzepatide) lists its half-life at 5 days. This means on day 5, 50% of the original dose is still active in your body.

I switched to a 5-day schedule after reaching 10mg and developing a slight tolerance. I believe I could have stayed at a lower dose if I'd done this sooner. The standard dosage escalation for Tirzepatide is 2.5, then 4, 7.5, 10, 12.5, and finally 15mg. Splitting the dose likely won't have the same effect.
 
That's the best advice. I only got 4 days out of all tirz doses from 2.5 all the way to 15. I kept doubling down thinking increasing the dose would help but i should have just switched to 5 days but I wasnt as educated back then!
 
Agreed. I dose Reta every 5 days and it really helps. I skipped splitting doses, but some people like it, so it may be an option for some.
 
Just to be clear, you're advocating for taking the full dose of Tirz every five days, as opposed to splitting it into two smaller doses over a week?

Like, 5mg on Monday night, then again on Saturday night, then the following Thursday night, etc., compared to 2.5mg on Monday night, then again on Thursday or Friday night, and then back to Monday, over and over.
 
I have a different opinion. I think staying on the lowest effective dose is better, both for your body and your wallet. If a low dose of tirz plus a low dose of cagrisema (or just cagri) works, that's better than needing 15mg of tirz every week.

Also, saying tirz is going to be a 'dead drug' is pretty ridiculous. I'd never touch sema because of the side effects, and reta isn't for me. Tirz has been great, and most people here are on tirz.
 
Hey Slightly_Smaller, check out GLP1Plotter.com or Steroidplotter.com to map out your dosing schedule. It will show how much of the drug will be in your system at any point.

I prefer Steroidplotter. The comment section has links to pharmacokinetic data for different drugs. You can even use this to build your own tool.
 
The issue is that there's no clinical research on Triz & CagriSema stacks. They've been tested alone, but not together. That's why the effects on your system are unknown.
 
What people use now doesn't matter. Phentermine used to be popular, but now, there are better options. Orlistat? Same thing. Nobody wants the oily disaster pants anymore. Atripla saved tons of lives from AIDS, but now there are better drugs.

Time will tell if I'm right. But once CagriSema and others get approved, everyone will switch, just like they did with Tirzepatide. Those phase 3 studies are amazing.

And stacking two different drugs to stay on the lowest dose is never a good idea!
 
I get what you're saying. But, for me, stacking two different things at low doses isn't about saving money or wanting to stay on the lowest dose to stack them.

I thought that while they're both GLP-1s, they do different things. Sema and cagri are better at controlling hunger than Tirz, but they often have more side effects, and they don't always work as well for weight loss.

By combining them at low doses (not on the same day, but 4 days apart), I'm hoping to get the best of both worlds as the effects of the first dose wear off while avoiding side effects.

And it worked! The worst I had was some slight nausea for a couple of hours.

I don't want to stack a bunch of drugs and expect miracles. I just want a combo that will help with the benefits of the drugs, long-term.
 
That's the great thing about doing your own research. What helps one person might not help another. And we have many tools available and more on the way. It sounds like what you're doing has been working for you. The most important thing is to do your research safely.
 
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