Tirz good enough, or switch?

[SlimInSeattle]

I'm on Tirzepatide now, lost 20+, but wondering if I should try Retatrutide or another one. Got about 30 more to shed, so curious about your experiences.

 

[Food_Strong]

Stick with the tirz. Reta spiked my heart rate way up to 130! Sema made me super sick to my stomach. And Cagri... forget about it, brain fog city.

 

[BoutiqueCompounding]

Test out a small amount of sema, like 0.5mg, and see how you feel. Considering you've used tirz, you should be ok. Most people only get hit with side effects with sema after exceeding 1mg doses.

 

[Macro-Clean]

What's making you want to switch? Is your weight loss stalled out, side effects getting to you, or just curious about the new meds?

 

[HeartCoffee]

Tirz worked well for me, but I moved to reta hoping it would help get rid of fat in my liver (my ALT levels are high) and keep me from losing muscle.

My resting heart rate went up like 12 bpm, which is kind of a lot. Tirz also bumped it up, but only by maybe 5.

If you don't have a good reason, don't change what's working.

 

[FitGirl]

Reta is kinda hyped up IMO. Saw someone claim it cured their ADHD which sounds sus. If you're trying to lose a lot with tirz, expect some slowdowns here and there. I'd try what Macro-Clean suggested before Reta.

 

[MedSet]

Start with a tiny dose and be patient. Treat the initial side effects to make yourself more comfortable. Side effects do get easier over time. Get medical advice for serious side effects, obv.

 

[HeartCoffee]

I've seen quite a few people talking about GLP1s and ADHD. The science seems to support the idea that they could help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489532/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696437/

They affect the dopamine reward system, which is thought to be off in people with ADHD.

I'm no expert, but it seems GLP1s could treat at least part of ADHD. If that's the biggest problem for someone, it might even seem like a "cure."

 

[Bio_FWIW]

How often are you taking your 15mg dose?

I'm doing 15mg every 6 days, close to 17.5mg per week. Trying to push the higher tirz doses before mixing or changing anything. Down 77lbs on tirz only, trying to see what it can do for these last 25ish pounds.

 

[Macro-Clean]

I'm doing the same thing with 15mg every 6 days, and it's been a huge help.

Congrats on losing 77lbs!

 

[Bio_FWIW]

Thanks! How long have you been on 15/6? Any plans to try 15/5, or just go straight to 20mg or 25mg every 7?

 

[BoutiqueCompounding]

How did tirz raise your heart rate when it doesn't affect glucagon? Glucagon can affect your HR (so reta can).

 

[Macro-Clean]

I've been doing it for a month. If I need to, I'll go up, but I hope I can stay at 15/6 for a while.

 

[Macro-Clean]

It's a known effect of tirz. It went up a lot at first, but it's back to normal now.

 

[BoutiqueCompounding]

I wonder if they'll do the same thing with reta later? The max dose is 12mg/week now. Maybe they'll go up to 16mg? Reta is stronger than tirz, IMO. Sema is stronger than both. I couldn't handle 1.5mg of sema without bad side effects. 0.8-1mg is my max. I could do 5, 7.5, 10, even 12.5 of tirz with just some fatigue the next day. Reta gave me racing thoughts at 2, 4, 6, 8mgs. But nothing compares to Sema at 0.8-1mg, I'd be throwing up and have diarrhea. Sema is strong...

 

[HeartCoffee]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286523/

Studies consistently show that tirzepatide can raise RHR.

 

[SlimInSeattle]

My research also shows that reta raises both average and RHR.

 

[SlimInSeattle]

RHR went up during 4 weeks of 1.25mg tirzepatide every 4 days:

 

[Food_Strong]

I've had great results with Reta. Sema and Tirz gave me stomach issues and low energy. And I got gout all the time, like every 2 weeks instead of 1-2 times a year.

I tried Reta after reading it helps with fatty liver, which I thought was causing some of my problems. 10 weeks in, down 27 lbs, no gout, no stomach problems, and good energy. My skin tags (fatty liver symptom) were gone in a month.

 

[Macro-Clean]

Now that you mention it, my skin tags are gone too.

Was that weight loss all on Reta, or did you lose some before with sema and tirz?

Congrats!