Just my two cents... Reta doesn't suppress my appetite as much at low doses. But, I love the fat burning effect. I have stacked Tirz and Reta. I've heard that appetite suppression kicks in at 6mg of Reta and above, then you can fully switch to Reta. I did something different. I went all the way up to 15mg on Tirz and slowly up to 5mg on Reta. The appetite suppression was so strong I could only handle it for 2 weeks. Then I titrated down on Tirz and up on Reta. I'm at 12mg Reta and 4mg Tirz. Honestly, I could stop the Tirz, but I have a lot left. I may drop the Tirz to 2mg soon if the Reta keeps suppressing my appetite. BTW, the only side effects were when I went from 5mg to 7.5mg Tirz (massive fatigue for 2 days) and when I jumped from 1mg to 3mg Reta (diarrhea for a week).