Tirzepatide and wicked acid reflux?

[Sarah56]

The day 1-2 heartburn that settles by day 3 is the pattern your coworker hit. Starting with the next dose lower rather than trying to push through it too fast is usually the recommendation. How far into the injection sequence is the OP and is it happening every time or just the first couple?

 

[pecan-strummer53]

The acid reflux appearing after titrating up to 2mg/week is consistent with what the slowed gastric emptying mechanism can do - stomach contents sitting longer, especially at night. Adjusting sleep timing relative to eating tends to help more than antacids for most people. How many hours after your last meal are you usually lying down?