Titration Troubles & Tolerance?

[thyme_simmerer]

That kind of even distribution across doses is actually really good - means the medication worked at every level rather than needing to push high to get results. Being sensitive and staying patient with titration paid off for you. 60 lbs across three dose levels is a clean outcome.

 

[noodle-potter88]

The slow-and-low default is sensible for side effect management but can become excessive caution that extends time at sub-therapeutic levels. If you've been tolerating the current dose well for several weeks with no meaningful side effects, the signal to go up is already there.

 

[mauve_intransit]

Follow the standard four week increase schedule, monitor how things feel at each step along the way, and if it ever feels like too much, scaling back down a level is always an option.

 

[workingonsteady54]

My provider's always pushing the lowest dose that still gets results. Bumping up every 4 weeks is the typical schedule, but if side effects show up or the weight's still coming off, there's no rush to increase on schedule. Can always go up slower too. Best to just listen to your own body.

 

[quietwalnut]

What dose are you currently at and how long have you been sitting there? Climbing higher should ease that up.

 

[salty_lateadopter51]

Why bother increasing the dose at all if weight keeps dropping, side effects stay minimal or manageable, and appetite noise remains low or nonexistent?

 

[misoweaver]

How's 20mg tirz working out for you? Considering bumping up myself, been sitting at 15mg for months now and still only losing half a pound a week on the good weeks. At 69 and a BMI in the high 40s, feels like I should be seeing more movement than that.

 

[stormySalmon]

Yeah I honestly wouldn't suggest climbing as fast as I did lol. Like mentioned, everyone reacts differently, and I kept nudging upward weekly while watching how my body responded until landing on the right amount. 6 mg was already working great, but I pushed to 9 and the weight's been dropping steadily, and I'm still managing to eat enough and hit my protein.

 

[chickpea-month651]

I stand as living proof against that theory. Still dropping weight on a maintenance amount of 2mg Tirz weekly. Maybe there's truth to what people claim, just not universally. Probably holds for someone who pushed up to higher amounts. Doesn't apply to those who stayed lower the whole way through. Began tirz at 2.5mg. Climbed to 5mg after a month and stayed there for 32 weeks straight. Down to 2mg maintenance for six weeks now. Weight's still coming off. Had rough patches too. Never assumed reaching my goal would happen purely from the medication alone. Some personal effort's required too. There've been times I pushed through cravings instead of just bumping the dose, knowing that path would only make things harder to walk back from later. Not ready to stop entirely just yet. But I will eventually

 

[lankysourdough45]

15mg Tirz is unfortunately where I've settled for maintenance. Layering reta in now hoping to jumpstart things again since I've been stuck at this same weight and dose for nearly a year. Pushed to 20mg Tirz, added Survo, then Cagri, none of it moved the scale. Good news is 15mg Tirz keeps my 80 pound loss steady, just wish that final number landed closer to 120.

 

[raisin_tirzgang]

The way I approached titration leaned on my own outcomes plus anecdotal reports from this community and elsewhere.

Given there are people who barely respond, some who respond intensely, and everyone spread between, the eventual maintenance amount could realistically land wherever your final increase happened to be.

Makes sense to stick with the smallest amount that keeps steady progress going rather than rushing higher.

On Tirz I've seen folks hit their target under 5mg while others need upwards of 30mg+

Whether you've hit a wall really depends on the individual, but personally I've held at 15mg for seventeen months and my weight's barely shifted a few pounds in either direction.
Could call that a wall, sure.

Though I've also loosened my calorie intake and started eating more freely.

 

[antsy_ramen7616]

246lb was my start, and the scale said 217 today. The appetite suppression hasn't left, to be clear, just not as strong as when I began at .5mg. At the .5 stage skipping meals seemed easy if I wanted and forget about food. As I've titrated up I haven't returned to that feeling. Rushing to higher doses would probably bring it back, and I would if I weren't still losing weight.