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Psoriatic Arthritis and the constant inflammation making 1400 calories not enough to lose is the metabolic picture that frustrates people for years before they find something that works. The OP back in the dance studio is the inflammation reduction story as much as the weight story. Movement...

7.5 to maintain at 5mg is a really satisfying progression to read. Finding that step-down where you hold without the plateau creep is the thing people spend months trying to figure out. Sounds like you landed in a good spot.

265 to 170 and almost two years of maintenance is the long-game result that proves it's sustainable. Setting goals that fit your actual height and age rather than an arbitrary number is the part that makes maintenance feel achievable rather than like a constant fight. 315 to 180 in the OP is the...

The first month of reading everything is the right approach before starting. The scary dosing chart that circulates on some forums comes from a very different context than standard GLP-1 use. Starting conservative and building from there is the approach that works for most people regardless of...

2 weeks is still too early to know if the Reta is adding anything. Most people don't notice it doing much until around the 4-6 week mark at a consistent dose. Appetite and energy are usually the first signals. Give it more time before drawing conclusions.

6 months on Tirz at max 5mg and then transitioning - two weeks into whatever came next is still in the adjustment window. The stomach issues the OP describes on both sema and tirz is where reta's different GI profile is worth exploring. What came after the 5mg Tirz and what are the last two...

The 0.25mg adjustment phase rather than therapeutic dose is the part that catches a lot of people. Appetite suppression at that level is inconsistent by design. Most people do not get a real read on what the medication is doing until they are at 0.5mg or above for a few weeks. What is the dose...

the lab freezer as the official milestone of being in the hobby is one of the more accurate community self-assessments - once the home freezer is sharing space with ice cream and the stability window starts mattering, the upgrade makes practical sense. the cost per year of compound protection...

My first month was similar - 0.5, 1, 1.5, 2 and appetite suppression really didn't kick in until week 4 either. I'm 5'7" around 210 too so similar starting point. Did going to 2.5 or 3 make a noticeable difference for you or did the effect level off?

The volume question depends entirely on the concentration - 40 units of a 2mg/mL prep is 0.8mg which is a reasonable starting dose, while 40 units of a 5mg/mL prep is 2mg which is higher. Always check what you're drawing against the concentration on the vial before assuming the unit count tells...

Once I hit my target, I'm planning to stay on reta for life with maybe MOTS-C for the metabolic edge. Anyone with insulin resistance seems like a candidate for this kind of maintenance. The gym five days a week makes sense now because I have actual energy. It's not just about the weight - it's a...

Well done, I am so happy for you. I went from a US size 22 to a US size 6 in three years. I still can't believe it when I see myself.

Regardless of my weight, I refuse to tuck in my shirt. Years of school uniforms will do that to you!

Our newer pens here ditched the last dose as of March or so. Haven't switched yet myself but multiple people confirmed no residual dose left in them now.

You sound genuinely motivated and have made real progress. Would love to hear what your dose progression looked like. Really inspiring.

That's awesome! It was the same for me. I started this journey because my usual button-ups were too tight across the chest. I had to buy XLs just to have something to wear. Nine weeks later, I can fit back into my old sizes.

you can usually keep running and lifting but the first weeks on this stuff can feel rough—lower energy, nausea, dizzy. i switched to semaglutide and didn't stop training just scaled it back. smaller pre-workout meals, more protein, hydration and electrolytes helped tons.

These meds slow your digestion way down. If you can't handle dairy, it's gonna sit in your system longer and make it worse. Or your body's just reacting to the dose bump.

people are biased about glp users because they don't understand how these work. add in not knowing what it's like to fight weight your whole life and yeah, judgment comes fast. gen x doesn't sugarcoat anyway.

He shouldn't have cut you off cold, should've tapered the dose till weight stabilized. You're back in titration mode — won't kick in again until it rebuilds. Might take weeks. Could also try switching to another GLP1 if nothing shifts soon.