Started back in March, so reta's been part of my week for 31 weeks now. Began at half a milligram for three weeks, then tried doubling it, hard no, worst acid reflux and indigestion going, took about four weeks to calm down between supplements and patience. Learned I need to sit on a dose around eight weeks before bumping, even then only quarter to half milligram steps. Currently at 2.75mg weekly. Pace is slow, I've made peace with it, gaining weight took years so losing it takes time too. Averaging just over a pound weekly, with stalls running two to three weeks before suddenly dropping a few pounds and moving again. Down 37 lbs, feeling the best in ages with way more energy. Only downside, cant sleep past 5am anymore, hate it since I was always a night owl, now ready for bed by 10pm.