Tirz hives... anyone else?

[Chris_79]

So, I've been on tirz for about 3 months now, and it's been going pretty well. No side effects, which is awesome. But then Thursday and Saturday morning I woke up with hives on my legs that just kept getting worse. Benadryl wasn't doing squat, so I had to call telehealth and get some prednisone. It's been a stressful week, so maybe it's just that, but I'm wondering if anyone else has had something similar happen and figured out it was the tirz?

 

[CellMom]

I haven’t experienced that personally, but I think I recall seeing others post pics of comparable reactions.

 

[Shannon_1995]

Ugh, that sounds awful! Hope you're feeling better soon!

 

[FastingFam]

Tirz can indeed trigger hives, eczema, and other skin issues. You can try over-the-counter antihistamines like Zyrtec or Allegra, taking them together. I'm a nurse, and telehealth could prescribe oral corticosteroids. Hope you feel better soon.

 

[Chris_79]

Thanks! I got some prednisone – taken three so far – plus Allegra and Benadryl. Seems like I'm finally starting to improve. Really hoping it's just stress and not the tirz causing this.

 

[FastingFam]

Totally, stress can bring on hives as well.

 

[HeartCoffee]

It's interesting that you mention hives, Chris_79. While tirzepatide is generally well-tolerated, hypersensitivity reactions can occur. Prednisone should help calm the inflammation. Keep an eye out for any other symptoms, such as difficulty breathing or swelling of the face, which could indicate a more serious allergic reaction requiring immediate medical attention.

 

[Drew_19]

I've been on semaglutide for about six months now and have dropped about 55 lbs. I'm currently at 176lbs. It’s been pretty amazing. I track my progress with a graph - it's so motivating to see the line going down! Congrats on your journey Chris_79! I hope the hives clear up soon!

 

[Chris_79]

Hey Drew_19, congrats on the weight loss! That's awesome! Hoping these hives go away soon. Was starting to feel really good about things before this.

 

[CellMom]

Yeah, I agree with FastingFam, stress can definitely cause hives. And Chris_79 keep an eye on things, as HeartCoffee said, any breathing issues, get to the ER immediately.

 

[salad-stacker]

Old vial collection is relatable. They pile up quick when you're going through them regularly.

 

[bored_cumin]

Anyone tried higher than 15 mg of tirzepatide? Or would stacking something else work better?

 

[edamame_stroller]

This matches my experience exactly. Glad I am not the only one.

 

[sortingoutoats51]

Vials are tough to crack. Bent needles happen when people get frustrated with the plastic.

 

[saltynoodle59]

the cross-compound histamine reaction pattern across sema, tirz, and reta with two different suppliers is pointing toward BAC water as the more likely variable than the peptide itself - the benzyl alcohol reaction is well-documented and can produce exactly the 5-7 day itch that persists after injection. switching to sterile water as the carrier for one vial is the cleanest test to isolate whether BAC is the actual trigger