Noticed both the mental noise dropping and my appetite shrinking on day one, but six months into Tirz now, I've come to see them as two completely separate things. There've been stretches where hunger crept back in strong, yet the quiet in my head around food never returned. My theory, could easily be wrong, is that the mental piece comes from how the drug interacts with the brain directly, while the physical hunger piece ties back to delayed stomach emptying, which tends to fade around the three-month mark on Tirz, so that early intense fullness stops showing up. Basically: quiet head equals brain effect, hunger equals physical effect.